Here are my suggestions:(1) Try to call the Column Supplier for some info of Chiral column. Maybe they have more information for your analyte. Or if you are lucky, ask them give you a favor -> provide a free chiral column for trial analysis.
(2) If the chiral column is not available, try to put some Quatemary Ammonium Salt in the mobile phase, it maybe obtains a better separation.
Good Luck, also thanks for your question and any update of your results in advance.
