The current global shortage of Acetonitrile has pushed us to find 5 ways to reduce thedependence on Acetonitrile
Option 1: Reduce column ID:
Reducing the HPLC column ID from 4.6 mm to 3.0 mm can result in > 50 % reduction in mobile phase consumption.
Option 2: Reduce particle size and column dimensions:
* Reduces solvent consumption
* Maintains resolution
* Reduces run time
Option 3: Reduce column length:
Option 4: Substitute Acetonitrile with Methanol:
http://www.phenomenex.com/images/methanal_replacement.gif
Option 5: Solvent recycling (Isocratic separations only)
Reference by Phenomenex.
