General, full scan is the most common form of data collection due to the ease of setup and the availability of spectral libraries for compound confirmation. That is to say: Signal for screening for unknowns or for structural information (CID).
SIM mode, on the other hand, offers significant improvement in sensitivity over full-scan.
SIM signal for quantification of target compounds.
How is Synchronous SIM/Scan performed? What are the benefits?
Synchronous SIM/Scan is an acquisition mode that enables collection of both SIM (Selected Ion Monitoring) data and full scan data in a single run.
The Agilent SIM/Scan mode combines the best of both SIM and full scan from a single sample injection to improve productivity.
Agilent MSD ChemStation's AutoSIM feature allows you to create a SIM method automatically from ANY existing full scan method. Once you create the SIM method you can run synchronous SIM/Scan.
The Agilent Synchronous SIM/Scan offers the following benefits:
• Confirmatory information – full scan data for library search capability.
•Maximun sensitivity - SIM data enables trace analysis.
•Automated setup conversion - The AutoSIM feature automatically processes full scan data of chemical standards into SIM acquisition parameters for use in the SIM/Scan method.
